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Y3735 |
()-Huperzine A |
02518-79-6 |
可根據(jù)客戶(hù)要求訂制 |
英文名稱(chēng)：()-Huperzine A
CAS號(hào)： 02518-79-6
分析標(biāo)準(zhǔn)品
分子式 C15H18N2O 分子量242.32
基本信息:
溶解性 易溶于氯仿，溶于甲醇、乙醇，微溶于水
存貯條件 儲(chǔ)存溫度2-8℃
描述
別名 (-)-石杉?jí)A甲;(-)-Selagine
生化機(jī)理
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
應(yīng)用 石杉?jí)A甲不僅通過(guò)抑制膽堿酯酶活性，還可以通過(guò)影響自由基系統(tǒng)，降低生長(zhǎng)抑素、細(xì)胞內(nèi)[Ca2+]、谷氨酸含量，提高鈣調(diào)蛋白(CaM)和鈣調(diào)蛋白的信使核糖核酸(CaM mRNA)表達(dá)水平等多種藥理機(jī)制，提高認(rèn)知功能和學(xué)習(xí)記憶能力。
存貯條件 儲(chǔ)存溫度2-8℃
描述
別名 (-)-石杉?jí)A甲;(-)-Selagine
生化機(jī)理
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
應(yīng)用 石杉?jí)A甲不僅通過(guò)抑制膽堿酯酶活性，還可以通過(guò)影響自由基系統(tǒng)，降低生長(zhǎng)抑素、細(xì)胞內(nèi)[Ca2+]、谷氨酸含量，提高鈣調(diào)蛋白(CaM)和鈣調(diào)蛋白的信使核糖核酸(CaM mRNA)表達(dá)水平等多種藥理機(jī)制，提高認(rèn)知功能和學(xué)習(xí)記憶能力。
